MMV085203

Overview

MMV085203 is a potent Plasmodium falciparum inhibitor, with a Pf TrxR EC 50 of 900 nM. MMV085203 exerts potent antimalarial activity against both blood‑stage and sexual‑stage Plasmodium falciparum parasites, with superior efficacy toward clinical isolates of high clonal diversity. MMV085203 modulates parasite redox homeostasis, induces ROS production, and elevates mitochondrial TCA cycle intermediates. MMV085203 can be used for the research of malaria.

Application

Products | Products > Disease Areas > Parasitic Infection | Products > Disease Areas > Plasmodium Infection | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Infection | Products > Signaling Pathways > Parasite | Products > Signaling Pathways > TrxR | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-182683
• CAS No.: 385419-89-6
• Molecular Formula: C22H22N2O3
• Molecular Weight: 362.42
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source