SD-965

Overview

SD-965 is a selective STAT3 PROTAC degrader with a DC 50 of 0.14 μM. SD-965 promotes the ubiquitination and degradation of STAT3 . SD-965 induces rapid, complete and persistent depletion of STAT3 protein. SD-965 induces tumor regression in mouse xenograft models of leukemia and lymphoma. (Pink: STAT3 Target protein ligand; Blue: Cereblon ligand ( HY-W1009348 ); Black: linker ( HY-W017522 )).

Application

Products | Products > Disease Areas > Blood Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-182922
• CAS No.: 3054394-56-5
• Molecular Formula: C56H65N10O17PS
• Molecular Weight: 1213.21
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source