PV-DPD-19

Overview

PV-DPD-19 is an autoinducer-2 ( AI-2 ) quorum sensing inhibitor. PV-DPD-19 reduces AI-2 production and inhibits the expression of multiple MSCRAMM s. In co-culture systems with Staphylococcus aureus , PV-DPD-19 decreases the production of pyocyanin and Elastase in Pseudomonas aeruginosa . PV-DPD-19 impairs the adhesion ability of Staphylococcus aureus to lung epithelial cells. PV-DPD-19 inhibits biofilm formation of Pseudomonas aeruginosa ( MBIC 50 = 27 μg/mL) and Staphylococcus aureus ( MBIC 50 = 35 μg/mL). PV-DPD-19 shows no cytotoxicity in both in vitro lung epithelial cell models and in vivo Galleria mellonella larva models.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Staphylococcus Aureus Infection | Products > Disease Areas > Pseudomonas Aeruginosa Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Elastase

Product Information

• Catalog No.: HY-182942
• CAS No.: 3112321-20-4
• Molecular Formula: C15H19NO5
• Molecular Weight: 293.32
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source