(Z)-GW 441756

Overview

(Z)-GW 441756 is a hepatocyte nuclear factor 4α ( HNF4α ) activator, with an EC 50 of 9.2 μM and a K a of 4.6 μM in human systems. (Z)-GW 441756 directly interacts with the ligand-binding domain of HNF4α via persistent hydrogen bonds and hydrophobic interactions within the binding pocket. (Z)-GW 441756 reduces the accumulation of triglycerides and total cholesterol . (Z)-GW 441756 inhibits ferroptosis through a non-antioxidant mechanism. (Z)-GW 441756 decreases plasma triglyceride and total cholesterol levels in animal models of hyperlipidemia. (Z)-GW 441756 can be used in studies related to hyperlipidemia.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Orphan Nuclear Receptor | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-18314B
• CAS No.: 504433-24-3
• Molecular Formula: C17H13N3O
• Molecular Weight: 275.30
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source