Osteoprotegerin

Overview

Osteoprotegerin (OPG) belongs to the tumor necrosis factor receptor ( TNFR ) superfamily . Osteoprotegerin blocks the RANKL - RANK interaction as well as the binding of TRAIL to its receptor. Osteoprotegerin activates NF-κB to induce the expression of ICAM-1 , VCAM-1 and E-selectin , and activates the phosphorylation of ERK1/2 . Osteoprotegerin regulates osteoclast activity, inhibits osteoclast maturation and formation, bone lysis and bone resorption, and increases bone mass. Osteoprotegerin regulates vascular endothelial cell function. Osteoprotegerin can be used in the research of cardio-cerebrovascular and bone-related diseases.

Application

Products | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > RANKL/RANK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Integrin | Products > Signaling Pathways > PERK

Product Information

• Catalog No.: HY-183516
• CAS No.: 19220-35-0
• Molecular Formula: C18H32O2
• Molecular Weight: 280.45
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source