RIPK1/RIPK3-PPI-IN-1

Overview

RIPK1/RIPK3-PPI-IN-1 is an orally active dual-target inhibitor of RIPK1 / RIPK3 , with a K d value of 2.4 nM for RIPK1 and 24 nM for RIPK3 . RIPK1/RIPK3-PPI-IN-1 inhibits the phosphorylation of RIPK1 , RIPK3 and MLKL , thereby suppressing necroptosis . RIPK1/RIPK3-PPI-IN-1 restores body temperature, improves survival rate, and reduces IL-1β / IL-6 levels in serum and multiple organs of Mus musculus, thus alleviating TNF-α -induced systemic inflammatory response syndrome. RIPK1/RIPK3-PPI-IN-1 can be used in research related to systemic inflammatory response syndrome.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > Necroptosis | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-183564
• CAS No.: 2915280-95-2
• Molecular Formula: C27H20F2N6O3S
• Molecular Weight: 546.55
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source