CSF1R-IN-27

Overview

CSF1R-IN-27 is a CSF1R inhibitor with oral effectiveness, kinome-wide selective profile, low cellular cytotoxicity, and CSF1R IC 50 values of 19 nM, 88 nM, 173 nM, 797 nM, 1448 nM, and >3000 nM. CSF1R-IN-27 suppresses M-CSF-induced phosphorylation of CSF1R , AKT , and ERK in macrophages, and inhibits hepatic p- CSF1R /p- AKT /p- ERK signaling. CSF1R-IN-27 reduces serum transaminase levels, improves hepatic histopathology, alleviates inflammatory cell infiltration, and decreases circulating TNF-α and IL-6 levels. CSF1R-IN-27 can be used for the research of acute liver injury.

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Disease | Products > Disease Areas > Liver Injury | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > PERK | Products > Signaling Pathways > Aminotransferases (Transaminases) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > c-Fms | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-183569
• CAS No.: 3034296-91-5
• Molecular Formula: C27H30F3N7O3
• Molecular Weight: 557.57
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source