KKL-55

Overview

KKL-55 is a broad-spectrum anti bacterial agent that inhibits the trans-translation pathway and the ClpXP protease. KKL-55 suppresses trans-translation of non-stop mRNA , interferes with the binding of EF-Tu to tmRNA, and inhibits the proteolysis of substrates by ClpXP. KKL-55 blocks spore germination of Bacillus anthracis and protects macrophages from damage induced by anthrax toxin. By virtue of its inhibitory effect on ClpXP, KKL-55 synergistically enhances the antibacterial activity of antibiotics against drug-resistant Staphylococcus aureus . KKL-55 can be used in studies related to bacterial infections.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Bacterial Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Others | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > mRNA

Product Information

• Catalog No.: HY-183851
• CAS No.: 639048-45-6
• Molecular Formula: C11H12ClN5O
• Molecular Weight: 265.70
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source