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| CTX0294885 Basic information |
| Product Name: | CTX0294885 | | Synonyms: | CTX-0294885; CTX 0294885; CTX0294885; CTX 0294885.;CS-1944;CS-1885;CTx0294885, >99%;CTX0294885;2-(5-chloro-2-(4-(piperazin-1-yl)phenylaMino)pyriMidin-4-ylaMino)-N-MethylbenzaMide;2-(5-chloro-2-(4-(piperazin-1-yl)phenylamino)pyrimidin-4-ylamino)-N-methylbenzamide CTX0294885;2-[[5-Chloro-2-[[4-(1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide | | CAS: | 1439934-41-4 | | MF: | C22H24ClN7O | | MW: | 437.93 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 1439934-41-4.mol |
| CTX0294885 Chemical Properties |
| density | 1.332±0.06 g/cm3(Predicted) | | solubility | ≥21.9 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O | | form | solid | | pka | 14.57±0.46(Predicted) |
| CTX0294885 Usage And Synthesis |
| Biological Activity | ctx-0294885 is a novel bisanilino pyrimidine. it has inhibitory activity towards a wild range of kinases in vitro. ctx-0294885 is capable of capturing more than half of the expressed kinome in mda-mb-231 cells. large-scale ctx-0294885-based affinity purification with lc−ms/ms identifies 235 protein kinases. ctx-0294885 binds additional kinases that were not identified from previous studies using other kinase capture reagents. it is further developed into a sepharose-supported kinase capture reagent. ctx-0294885 is a new tool for analysis of kinome signaling networks. [1] | | references | 1. zhang l, holmes ip, hochgräfe f et al. characterization of the novel broad-spectrumkinase inhibitor ctx-0294885 as an affinity reagent for mass spectrometry-basedkinome profiling. j proteome res. 2013 jul 5;12(7):3104-16. |
| CTX0294885 Preparation Products And Raw materials |
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