TEAD degrader-1

Overview

TEAD degrader-1 is a potent FBXO22 -mediated molecular glue degrader of TEAD , with a 24 h DC 50 of 1.0 nM. TEAD degrader-1 binds reversibly and covalently to FBXO22 C326, assembles a functional ternary complex, and mediates proteasomal degradation of TEAD . TEAD degrader-1 exhibits high selectivity for the Hippo pathway and specifically downregulates only TEAD and its downstream target proteins. TEAD degrader-1 is applicable to research related to malignant pleural mesothelioma and non-small cell lung cancer .

Application

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Product Information

• Catalog No.: HY-184179
• CAS No.: 3103984-17-1
• Molecular Formula: C36H38ClF2N3O6
• Molecular Weight: 682.15
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source