PROTAC TEAD degrader-3 is a TEAD PROTAC degrader with an IC 50 of < 5 nM against TEAD1, TEAD2, TEAD3 and TEAD4. PROTAC TEAD degrader-3 promotes ubiquitination and degradation of TEAD1/2/3/4. PROTAC TEAD degrader-3 can be used in cancer research. (Pink: TEAD1 and TEAD2 and TEAD3 and TEAD4 ligand ( HY-186023 ); Blue: E3 ligase ligand; Black: linker).
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