Mito-Esculetin

Overview

Mito-Esculetin (Mito-Esc) is an orally active mitochondria-targeted derivative of Esculetin ( HY-N0284 ). Mito-Esculetin inhibits LPS-induced phosphorylation of STAT3 Tyr-705, partially reverses LPS-mediated depletion of SIRT3 , and enhances the AMPK-SIRT1 signaling axis. Mito-Esculetin inhibits PAI-1 activity, regulates miRNA , and induces phosphorylation of IRS and AKT . Mito-Esculetin suppresses oxidant-induced endothelial dysfunction, Ang-II ( HY-13948 )- and high glucose-induced atherosclerotic plaque formation, Palmitate ( HY-N0830 )-induced insulin resistance, as well as high glucose-mediated endothelial cell senescence and inflammatory responses. Mito-Esculetin reduces body weight and non-esterified fatty acid (NEFA) levels. Mito-Esculetin can be used in research related to acute coronary syndrome, type 2 diabetes, and hyperglycemia-induced atherosclerosis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Atherosclerosis and Inflammation | Products > Disease Areas > Type 2 Diabetes | Products > Signaling Pathways > Others | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > PAI-1 | Products > Signaling Pathways > MicroRNA | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > Drug Derivative

Product Information

• Catalog No.: HY-184265
• CAS No.: 1993461-76-9
• Molecular Formula: C35H36BrO4P
• Molecular Weight: 631.54
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source