DDO-88109

Overview

DDO-88109 is a STING inhibitor with a K d value of 317 nM for hSTING and 0.625 μM for mSTING. DDO-88109 competitively occupies the CDN-binding pocket of STING , thereby maintaining STING in an inactive state. It inhibits cGAS-STING signaling—including STING translocation from the endoplasmic reticulum to the Golgi apparatus, STING oligomerization, and the phosphorylation of IRF3 , p65 , TBK1 , and STING—and attenuates the production of inflammatory cytokines and tissue inflammation in mouse models of TREX1-deficiency-driven autoinflammation and cisplatin ( HY-17394 )-induced acute kidney injury. DDO-88109 is suitable for research on inflammatory diseases, autoimmune disorders, and acute kidney injury driven by the cGAS-STING pathway.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Renal Disease | Products > Disease Areas > Systemic Lupus Erythematosus | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Endocrinology | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > STING

Product Information

• Catalog No.: HY-184502
• CAS No.: 3034295-80-9
• Molecular Formula: C24H23BrN2O
• Molecular Weight: 435.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source