SMD-6346

Overview

SMD-6346 is an orally active SMARCA2 PROTAC degrader with a DC 50 of 3.3 nM. SMD-6346 induces SMARCA2 degradation and exhibits extremely low activity against SMARCA4. SMD-6346 inhibits the growth of SMARCA4-deficient cancer cells and suppresses tumor growth in mouse xenograft models. SMD-6346 can be used for the research of non-small cell lung cancer . (Pink: SMARCA2 ligand ( HY-170817 ); Blue: Cereblon ligand ( HY-W440247 ); Black: linker).

Application

Products | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SWI/SNF Complex

Product Information

• Catalog No.: HY-184673
• CAS No.: 3086248-19-0
• Molecular Formula: C46H50ClF2N5O4
• Molecular Weight: 810.37
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source