Urease-IN-24

Overview

Urease-IN-24 is a cryptococcal urease inhibitor with a IC 50 of 89.96 nM and a K i of 64.3 nM. Urease-IN-24 acts as a competitive nickel-coordinating inhibitor that coordinates with the nickel center at the catalytic site of the enzyme via its carbonyl group. Urease-IN-24 reduces the capsule thickness of Cryptococcus neoformans and Cryptococcus gattii , increases cell membrane permeability, and inhibits melanin production. Urease-IN-24 exhibits fungicidal activity against Cryptococcus species. Urease-IN-24 can be used in the research of cryptococcosis.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Fungal Infection | Products > Disease Areas > Cryptococcal Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Urease | Products > Signaling Pathways > Fungal

Product Information

• Catalog No.: HY-184981
• CAS No.: 2243516-99-4
• Molecular Formula: C14H16N2O3Se
• Molecular Weight: 339.25
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source