PIPE-791

Overview

PIPE-791 is an orally active, blood-brain barrier-permeable selective antagonist of LPAR1 . PIPE-791 inhibits LPA-induced calcium mobilization, collagen expression, histamine release, and the activation of fibroblasts, microglia and macrophages. PIPE-791 induces oligodendrocyte precursor cell differentiation, myelination and remyelination, and increases the number of microglia in the retina of normotensive rats. PIPE-791 protects mature oligodendrocytes from cytokine-induced death, reduces the levels of pulmonary fibrosis markers and alleviates neuroinflammation in preclinical models. PIPE-791 can be used in the research of glaucoma, neuroinflammatory diseases, chronic osteoarthritis pain, idiopathic pulmonary fibrosis and multiple sclerosis.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Visual System Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > CNS Infection | Products > Disease Areas > Arthritis | Products > Disease Areas > Glaucoma | Products > Disease Areas > Multiple Sclerosis | Products > Disease Areas > Lung Fibrosis | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > LPL Receptor | Products > Signaling Pathways > Histamine Receptor | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-184986
• CAS No.: 2901868-37-7
• Molecular Formula: C24H29F2N3O5
• Molecular Weight: 477.50
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source