STING antagonist-3

Overview

STING antagonist-3 is a potent STING antagonist with an IC 50 of 2.3 nM against human wild-type STING . STING antagonist-3 inhibits human wild-type STING and the gain-of-function STING mutants N154S and V155M. STING antagonist-3 suppresses IFN‑α2a production in stimulated human whole blood. STING antagonist-3 inhibits IP-10 production in activated human dermal microvascular endothelial cells (HMVEC-d). STING antagonist-3 can be used for the research of autoimmune diseases, autoinflammatory diseases, interferonopathies, and fibrotic disorders.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Autoimmune Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > STING

Product Information

• Catalog No.: HY-185379
• CAS No.: 3106554-00-8
• Molecular Formula: C35H39N5O3
• Molecular Weight: 577.72
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source