seco-CBI dimer

Overview

seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs) . seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma.

Application

Products | Products > Disease Areas > Non-Hodgkin Lymphoma | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA Alkylator/Crosslinker | Products > Signaling Pathways > ADC Payloads

Product Information

• Catalog No.: HY-185488
• CAS No.: 2592397-70-9
• Molecular Formula: C41H36Cl2N4O5
• Molecular Weight: 735.65
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source