F6OM, a nonionic fluorinated octyl maltoside derivative, is a surfactant. F6OM readily interacts with and completely solubilizes phospholipid vesicles via a heterogeneous solubilization mechanism, without compromising membrane order at subsolubilizing concentrations. F6OM promotes bilayer insertion of an integral membrane enzyme in the absence of micelles to support functional refolding of integral membrane proteins. F6OM can be used for membrane-protein applications.
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