dTAG-TRIMTAC is a PROTAC -like degrader targeting TRIM21 . dTAG-TRIMTAC forms a ternary complex with TRIM21 and target proteins to drive degradation of oligomeric/assembled substrates via TRIM21 clustering-based activation, with degradation dependent on endogenous TRIM21 . dTAG-TRIMTAC can be used for the research of neurodegenerative disease and inflammatory disease.
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