HOOC-OXA-COOH is an anionic prodrug of Oxaliplatin ( HY-17371 ). HOOC-OXA-COOH can be loaded onto nanomotors via electrostatic interaction, and undergoes cascade activation by H 2 S and endogenous glutathione in the tumor microenvironment to release cytotoxic Pt 2+ . HOOC-OXA-COOH can be used in the research of colon cancer .
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