KVL-9

Overview

KVL-9 is an intermediate used for constructing KRAS degrading antibody conjugates ( DACs ). KVL-9 consists of a KRAS small molecule binder, spacer, VHL recruitment ligand, and a cleavable antibody linker. KVL-9 achieves antigen-dependent intracellular delivery and induces ubiquitin-proteasome degradation of the KRAS protein mediated by VHL by conjugating with tumor antigen-targeting antibodies.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTAC-Linker Conjugates for PAC | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-186226
• CAS No.: 3113309-33-1
• Molecular Formula: C140H192F2N38O34S2
• Molecular Weight: 3053.38
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source