Trequinsin

Overview

Trequinsin (HL 725 free base) is a PDE inhibitor, CatSper channel activator, and sperm potassium channel modulator. Trequinsin targets PDE3 with an IC 50 of <1 nM. Trequinsin enhances currents and elevates intracellular calcium and cGMP levels via direct activation of the CatSper channel, while inhibiting the outward current conductance of sperm potassium channels. Without inducing premature acrosome reaction, Trequinsin significantly enhances sperm hyperactivated motility, forward motility, and the ability to penetrate viscous media. Trequinsin exerts age-specific positive inotropic and positive lusitropic effects on rabbit ventricular papillary muscles. Trequinsin has been used in studies on the mechanisms underlying male infertility (e.g., asthenozoospermia).

Application

Products | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Male Reproductive System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Phosphodiesterase (PDE)

Product Information

• Catalog No.: HY-18740
• CAS No.: 79855-88-2
• Molecular Formula: C24H27N3O3
• Molecular Weight: 405.50
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source