Sitamaquine

Overview

Sitamaquine (WR 6026) is an orally active Antileishmanial agent and Succinate dehydrogenase inhibitor. Sitamaquine accumulates in the acidocalcisomes of Leishmania , induces organelle alkalization, and crosses the plasma membrane of Leishmania via temperature- and energy-independent diffusion. Sitamaquine disrupts oxidative phosphorylation in Leishmania , induces mitochondrial depolarization, oxidative stress, elevated intracellular calcium, plasma membrane depolarization, and Apoptosis -like cell death. Sitamaquine can be used in the research of leishmaniasis.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Parasitic Infection | Products > Disease Areas > Leishmania Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Infection | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > Parasite | Products > Signaling Pathways > Succinate Dehydrogenase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-19688
• CAS No.: 57695-04-2
• Molecular Formula: C21H33N3O
• Molecular Weight: 343.52
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source