ZNL-02-096

Overview

ZNL-02-096 is a selective Wee1 PROTAC degrader. ZNL-02-096 binds to CRBN and Wee1 to form a ternary complex, inducing CRBN - and proteasome-dependent ubiquitination and proteasomal degradation of Wee1 . ZNL-02-096 inhibits recombinant PLK1 with an IC 50 of 102 nM, but does not induce its degradation in cells. ZNL-02-096 induces G 2 /M phase arrest, Apoptosis , transient integrated stress response, upregulation of ATF4 , and phosphorylation of GCN2 . ZNL-02-096 reduces Tyr15 phosphorylation of CDK1 . ZNL-02-096 can be used in research related to ovarian cancer , acute lymphoblastic leukemia, triple-negative breast cancer , multiple myeloma, and pancreatic ductal adenocarcinoma. (Pink: Wee1 ligand ( HY-10993 ); Blue: Cereblon ligand ( HY-W1005059 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Blood Disease | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Acute Lymphoblastic Leukemia | Products > Disease Areas > Multiple Myeloma | Products > Disease Areas > Pancreatic Ductal Adenocarcinoma | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > Eukaryotic Initiation Factor (eIF) | Products > Signaling Pathways > CDK | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Wee1 | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-208742
• CAS No.: 2414418-56-5
• Molecular Formula: C43H47N11O6
• Molecular Weight: 813.90
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source