HMRef-αMan

Overview

HMRef-αMan is a substrate-based green fluorescent probe (Ex/Em=465 nm/515 nm) targeting MAN2C1 (α-mannosidase) . HMRef-αMan can be specifically cleaved by MAN2C1 to generate a highly fluorescent product, which thus gets activated to produce green fluorescence in malignant breast tissues, benign lesions and living cancer cells. The signal intensity of HMRef-αMan is directly correlated with MAN2C1 activity, and it can effectively detect tiny breast cancer lesions with a diameter of less than 1 mm. When used in combination with the red-emitting γ-glutamyl transpeptidase ( GGT ) probe gGlu-2OMe SiR600 ( HY-D3188 ), HMRef-αMan enables precise optical differentiation of breast tissue types via a dual-color imaging strategy. HMRef-αMan has been widely used in the research of breast diseases such as breast cancer , fibroadenoma, phyllodes tumor and various types of papilloma.

Application

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Product Information

• Catalog No.: HY-D3187
• CAS No.: 2484831-02-7
• Molecular Formula: C28H26F3NO8
• Molecular Weight: 561.50
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source