Dns-LLC is a cell-permeable Cu + -selective fluorescent probe that forms a 1:1 complex with Cu + . The thiol group of Dns-LLC plays a key binding role, while the sulfonamide and amide groups jointly contribute to the stabilization of the complex. Upon binding to Cu + in aqueous buffer solutions, Dns-LLC generates a turn-on fluorescence response, which can be used for the detection of Cu + in the Golgi apparatus.
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