Hydroxysaikosaponin D is a hepatocytoprotective saponin found in the roots of Bupleurum scorzonerifolium WILLD. Hydroxysaikosaponin D inhibits D-galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Hydroxysaikosaponin D mitigates D-galactosamine/LPS-induced liver injury in mice. Hydroxysaikosaponin D can be used for the research of liver injury.
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