MS-347a is an inhibitor of myosin light chain kinase ( MLCK ) and protein kinase C ( PKC ), with IC 50 values of 9.2 μM, 31 μM and 16 μM against calmodulin-dependent MLCK, calmodulin-independent MLCK and PKC , respectively. MS-347a binds to the catalytic domain of MLCK and blocks both calmodulin-dependent and calmodulin-independent MLCK activity. MS-347a inhibits the growth of drug-sensitive fission yeast and multiple ascomycete phytopathogenic fungi. MS-347a exhibits fungicidal activity against a variety of phytopathogenic fungi and protective activity against Magnaporthe oryzae in rice seedlings. MS-347a shows antibacterial activity against specific Gram-positive bacteria and Proteus vulgaris . MS-347a can be used in studies related to rice blast, bacterial infections and phytopathogenic fungal diseases.
Products | Products > Disease Areas > Infection | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Fungal Infection | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Myosin | Products > Signaling Pathways > PKC | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > Fungal
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