Verticilatin is a prenylated diaryl ether derived from phytopathogenic fungi, acting as an antibacterial agent and biofilm inhibitor. Verticilatin exhibits no direct growth inhibitory activity against Gram-negative bacteria. Verticilatin effectively inhibits the growth of Gram-positive strains, including methicillin-sensitive/resistant Staphylococcus aureus and Enterococcus faecalis , and reduces the biofilm-forming ability of Gram-negative Stenotrophomonas maltophilia . Verticilatin can be used for infections caused by the aforementioned Gram-positive bacteria and biofilm infections caused by Stenotrophomonas maltophilia .
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