(2E,6E,10E)-12-Hydroxyfarnesol is a metabolite of Farnesol ( HY-Y0248A ). (2E,6E,10E)-12-Hydroxyfarnesol forms via CYP2E1 - and CYP2C19 -mediated ω-hydroxylation of Farnesol in mammalian systems, and via CYP2E1 -catalyzed selective hydroxylation of Farnesol in mammalian cells. (2E,6E,10E)-12-Hydroxyfarnesol is produced by the endophytic fungus Aspergillus sp. AST0006. When cholesterol synthesis is blocked, (2E,6E,10E)-12-Hydroxyfarnesol acts as a precursor for the formation of α,β-dicarboxylic acid.
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