Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti- parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC 50 of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca 2+ -ATPase . Nummularine B is applicable to research related to malaria and visceral leishmaniasis.
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