PNU-142586 sodium

Overview

PNU-142586 sodiu) is the major metabolite of Linezolid ( HY-10394 ). PNU-142586 can inhibit the activity of DNA topoisomerase 2-α ( TOP2A ) and DNA topoisomerase 2-β ( TOP2B ). PNU-142586 interferes with DNA replication and transcription by blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis, ultimately leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 can be used to study Linezolid -induced hematotoxicity and its molecular mechanism.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Others | Products > Signaling Pathways > Topoisomerase | Products > Signaling Pathways > Drug Metabolite

Product Information

• Catalog No.: HY-W654323
• CAS No.: 2468637-62-7
• Molecular Formula: C16H19FN3NaO6
• Molecular Weight: 391.33
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source