Ethalfluralin is a dinitroaniline herbicide and microtubule inhibitor. Ethalfluralin blocks nuclear division and cytokinesis of parasites by inhibiting intranuclear spindle formation. Ethalfluralin activates the phosphorylation levels of NF-κB and P38 MAPK , inhibits the PI3K/AKT signaling pathway, impairs mitochondrial function, and induces apoptosis , endoplasmic reticulum stress, autophagy , and ROS production. Ethalfluralin is applicable to research related to toxoplasmosis.
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