Bromuconazole

Overview

Bromuconazole is a triazole fungicide with oral efficacy and blood-brain barrier permeability . Bromuconazole protects crops from various fungal contaminations. Bromuconazole exhibits cytotoxicity against a variety of cancer cells, induces G0/G1 cell cycle arrest and inhibits DNA synthesis in cancer cells, and triggers cytoskeletal structural disorder, genotoxic damage, apoptotic ( apoptosis ) cell death, and mitochondrial membrane depolarization. Bromuconazole activates caspase-3 , induces excessive production of ROS, p53 and Bax , lipid peroxidation, increased activities of SOD and CAT , and downregulates Bcl-2 . By upregulating p-ERK1/2 and p-JNK , Bromuconazole disrupts the MAPK signaling pathway, impairs the cellular stress response of human trophoblast cells and endometrial cells, and damages the implantation process . Bromuconazole is applicable to research related to glioma, colon cancer , reproductive injury (implantation dysfunction), and cardiac dysfunction.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Glioma | Products > Disease Areas > Fungal Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Infection | Products > Research Areas > Endocrinology | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > SOD | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > PERK | Products > Signaling Pathways > JNK | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Fungal

Product Information

• Catalog No.: HY-W715812
• CAS No.: 116255-48-2
• Molecular Formula: C13H12BrCl2N3O
• Molecular Weight: 377.06
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source