N-butyl lithocholic acid is a derivative of the secondary bile acid lithocholic acid. Lipid nanoparticles (LNPs) formulated with N-butyl lithocholic acid and encapsulating an mRNA vaccine encoding influenza hemagglutinin demonstrate reduced toxicity in the heart, spleen, and liver compared to LNPs containing cholesterol in mice.
Products > Lipids In Drug Delivery > Cholesterol | Products > Lipids In Drug Delivery > Cholesterol > Cholesterol
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