PDRN

Overview

PDRN (Polydeoxyribonucleotide) is a deoxynucleotide polymer mainly derived from the sperm of rainbow trout or salmon. PDRN inhibits pro-inflammatory factors and promotes VEGF expression via the cAMP-PKA pathway by activating the adenosine A 2A receptor ( A 2A R ), thereby driving angiogenesis and collagen deposition in fibroblasts. Degradation products of PDRN provide DNA raw materials for proliferating cells through the salvage synthesis pathway, accelerating re-epithelialization. PDRN reduces melanin synthesis and cell apoptosis by upregulating ERK/AKT phosphorylation and inhibiting the activities of MITF and tyrosinase , and resists skin aging by attenuating nuclear autophagy and blocking the interaction between LC3-SIRT1 . PDRN is mainly used for wound repair, post-aesthetic surgery recovery and anti-aging research.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Cellular Senescence | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Adenosine Receptor | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > PKA | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Microphthalmia Associated Transcription Factor (MITF) | Products > Signaling Pathways > Tyrosinase | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-W250160
• CAS No.: 100403-24-5
• Molecular Formula: C9H10FN3O3
• Molecular Weight: 227.19
• Purity: 90.20%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source