SJ988497 is a PROTAC molecule designed to degrade JAK2, effectively inhibiting cell proliferation in CRLF2-rearranged cell lines. It also promotes the degradation of the CRBN neosubstrate GSPT1. Structurally, it includes a Ruxolitinib derivative, a linker, and a CRBN ligand (Pomalidomide), making it useful for studying protein degradation mechanisms. Reagent-grade; for laboratory research purposes only.
Products > PROTAC, Molecular glue > Degraders
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