Pomalidomide-CO-C5-Br is a PROTAC linker featuring a pomalidomide, an aliphatic spacer, and a bromide. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction. Meanwhile, the bromide is easily displaced in substitution reactions.
PROTAC > PROTAC Linkers > PROTAC Linkers | Products > PROTAC, Molecular glue > PROTAC Linkers | Products > PROTAC, Molecular glue > PROTAC Linkers > Pomalidomide-amido-bromide | Products > PROTAC, Molecular glue > PROTAC Linkers > Pomalidomide-amido-bromide
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