C14-4

Overview

C14-4, an ionizable cationic lipid with a pKa of 6.5, has been employed in lipid nanoparticles (LNPs) for mRNA delivery. These LNPs, containing C14-4 and mRNA encoding a chimeric antigen receptor (CAR), effectively induce CAR expression in human T cells ex vivo, comparable to electroporation but with less toxicity. Additionally, they exhibit cytotoxicity against Nalm-6 leukemia cells in vitro. The pKa is 6.51.

Application

PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Ionizable Lipid | PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Branched Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Ionizable Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Branched Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid > Multi chargeable lipid | Products > Lipids In Drug Delivery > Branched Lipid > Branched Lipid

Product Information

• Catalog No.: BP-40860
• CAS No.: 2639634-80-1
• Molecular Formula: C84H173N5O7
• Molecular Weight: 1365.3
• Storage: -20°C
• Availability: In Stock

Source

Original product source