4-Nitrophenylhydrazine

CAS No.：100-16-3

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4-Nitrophenylhydrazine Basic information

Product Name:	4-Nitrophenylhydrazine
Synonyms:	1-(4-NITROPHENYL)HYDRAZINE;(4-nitrophenyl)-hydrazin;(p-nitrophenyl)-hydrazin;Hydrazine, (4-nitrophenyl)-;Hydrazine, (p-nitrophenyl)-;Hydrazine,(4-nitrophenyl)-;p-Hydrazinonitrobenzene;p-Nitrophenylhydrazide
CAS:	100-16-3
MF:	C6H7N3O2
MW:	153.14
EINECS:	202-824-8
Product Categories:	Phenylhydrazine;HydrazinesDerivatization Reagents;Derivatization Reagents HPLC;Nitrogen Compounds;Organic Building Blocks;UV-VIS;Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
Mol File:	100-16-3.mol

4-Nitrophenylhydrazine Chemical Properties

Melting point	156 °C (dec.)(lit.)
Boiling point	276.04°C (rough estimate)
density	1.00
refractive index	1.6910 (estimate)
storage temp.	Explosives area
pka	3.81±0.20(Predicted)
color	Orange-red leaflets or needles
Water Solubility	soluble in hot water
Merck	14,6624
BRN	608107
CAS DataBase Reference	100-16-3(CAS DataBase Reference)
NIST Chemistry Reference	P-nitrophenyl hydrazine(100-16-3)
EPA Substance Registry System	Hydrazine, (4-nitrophenyl)- (100-16-3)

Safety Information

Hazard Codes	F,Xn
Risk Statements	5-11-22-36/37/38-43-21/22
Safety Statements	16-26-36/37/39-37/39-36
RIDADR	UN 3376 4.1/PG 1
WGK Germany	3
RTECS	MV8225000
F	4.6
Hazard Note	Flammable/Harmful
HazardClass	4.1
PackingGroup	I
HS Code	29280000
Toxicity	mmo-sat 2 mmol/L AEMIDF 44,801,82

MSDS Information

Provider	Language
4-Nitrophenylhydrazine	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Nitrophenylhydrazine Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	Analytical reagent (aldehydes, ketones).
Uses	4-Nitrophenylhydrazine is a nitro substituted aryl hydrazine with potential anticancer activity. Irritant.
Definition	ChEBI: A member of the class of phenylhydrazines that is phenylhydrazine substituted at the 4-position by a nitro group.
General Description	4-Nitrophenylhydrazine is a orange-red leaflet or needles wetted with water. 4-Nitrophenylhydrazine will emit toxic oxides of nitrogen when heated to decomposition. 4-Nitrophenylhydrazine is slightly heavier than water and insoluble in water. 4-Nitrophenylhydrazine may be irritating to skin, eyes and mucous membranes. 4-Nitrophenylhydrazine may be toxic by ingestion. 4-Nitrophenylhydrazine may be explosive and sensitive to friction in the dry state. 4-Nitrophenylhydrazine is used as a reagent for ketones and aliphatic aldehydes.
Reactivity Profile	4-NITROPHENYLHYDRAZINE is a powerful explosive. 4-Nitrophenylhydrazine can SELF-IGNITE in the presence of contaminants. Auto-ignition temperature may vary for 4-nitrophenylhydrazine similar to that of hydrazine which has an autoignition of as low as 74oC in contact with iron rust. Dangerous fire hazard or severe explosion can occur when exposed to heat, flame or oxidizing agents. Severe explosion may also occur by chemical reaction with alkali metals; BaO; CaO; K; Na; NH3; Cl2; chromates; CuO; Cu++ salts; F2; H2O2; iron rust; metallic oxides; PbO2;Ni; Ni(ClO4)2; HNO3; N2O; O2; liquid O2; K2Cr2O7; Na2Cr2O7; tetryl; zinc diamide; Zn(C2H5)2. Dangerous; when heated to decomposition 4-Nitrophenylhydrazine emits highly toxic nitrogen compounds; may explode by heat or chemical reaction. (Sax and Lewis, 1987) under Hydrazine p. 538-539.
Health Hazard	Some are toxic and may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.
Safety Profile	Poison by intraperitoneal route.Mutation data reported. When heated to decomposition itemits toxic fumes of NOx. See also NITROCOMPOUNDS OF AROMATIC HYDROCARBONS
Purification Methods	Crystallise the hydrazine from EtOH. The hydrochloride has m 212o(dec) (from EtOH, also m 202-203o dec). [Beilstein 15 III 331, 15 IV 317.]

4-Nitrophenylhydrazine Preparation Products And Raw materials

Raw materials	Sodium sulfite-->Sodium acetate-->4-Nitroaniline-->Phenylhydrazine hydrochloride
Preparation Products	5-Nitroindole-->5-amino-1H-Indole-2-carboxylic acid ethyl ester-->ETHYL 5-AMINO-1H-INDOLE-2-CARBOXYLATE-->2,3,5-Trimethylthiophene-->1-METHYL-5-NITRO-1H-INDOLE-->Ethyl 5-nitroindole-2-carboxylate-->5-Aminoindole-->Nitrotetrazolium blue chloride-->4-THIOPHEN-2-YLPHENYLAMINE-->2-METHYL-5-NITROINDOLE-->1-(4-NITROPHENYL)-3-METHYL-5-PYRAZOLONE-->4-Nitrobiphenyl-->carbazol-3-ylamine

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