Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. The cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported. It has had many reported applications in biological labeling and imaging.
Polyethylene Glycol PEG Linkers > TCO PEG > TCO-OH & TCO-PEG-OH
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