dTAGV-1

Overview

dTAGV-1 represents a degrader designed to target fusion proteins involving mutant FKBP12F36V. It consists of a ligand specifically tailored for the F36V single-point mutated FKBP12, a linker, and a ligand binding to von Hippel-Lindau (VHL). This compound effectively induces robust and selective degradation of FKBP12F36V fusion proteins, demonstrating its efficacy both in vitro and in vivo. Reagent-grade; for laboratory research purposes only.

Application

Products > PROTAC, Molecular glue > Degraders

Product Information

• Catalog No.: BP-41592
• CAS No.: 2624313-15-9
• Molecular Formula: C70H91F3N6O16S
• Molecular Weight: 1361.6
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source