MS 436 CAS:1395084-25-9 is a potent and selective BRD4 bromodomain inhibitor (Ki of the first bromodomain (BRD4(1)) = 30 - 50 nM), MS436 exhibits in a panel of water-mediated interactions Low nanomolar affinity (estimated Ki is 30-50 nM), with 10-fold selectivity for BRD4(1) over BRD4(2).
Polyethylene Glycol PEG Linkers > PROTAC Linker > BET Inhibitors
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