tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate

Overview

tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate is a PROTAC linker featuring a thalidomide analogue, a hydrophilic PEG spacer, and a t-butyl ester. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. Meanwhile, the t-butyl ester can be hydrolyzed to reveal a carboxylic acid for further derivitization.

Application

PROTAC > PROTAC Linkers > PROTAC Linkers | Products > PROTAC, Molecular glue > PROTAC Linkers | Products > PROTAC, Molecular glue > PROTAC Linkers > Thalidomide-O-t-Boc | Products > PROTAC, Molecular glue > PROTAC Linkers > Thalidomide-O-t-Boc

Product Information

• Catalog No.: BP-40562
• CAS No.: 1950635-36-5
• Molecular Formula: C19H20N2O7
• Molecular Weight: 388.4
• Storage: -20°C
• Availability: In Stock

Source

Original product source