PFI 4

Overview

PFI 4 is an SGC chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) scaffolding protein BRPF1B. PFI 4 specifically binds to BRPF1B with an IC50 = 172 nM and Kd =13 nM as determined by ITC. PFI 4 reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250nM, while showing no effect on BRPF1A. PFI 4 exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Please contact us for GMP-grade inquiries.

Application

Products > PROTAC, Molecular glue > Inhibitors

Product Information

• Catalog No.: BP-25373
• CAS No.: 900305-37-5
• Molecular Formula: C21H24N4O3
• Molecular Weight: 380.5
• Storage: -20°C
• Availability: In Stock

Source

Original product source