XMD 8-92

Overview

XMD 8-92 is shown to be an extremely selective ERK5 (BMK 1) inhibitor that presents selectivity over 402 diverse kinases. XMD 8-92 shows Kd values of 80 and 190 nM for ERK5 (BMK1) and BRD4 inhibition, respectively. XMD 8-92 also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). XMD 8-92 has been shown to block growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. XMD 8-92 reduces BMK1-dependent transactivating activity of MEF2C. Please contact us for GMP-grade inquiries.

Application

Products > PROTAC, Molecular glue > Inhibitors

Product Information

• Catalog No.: BP-25377
• CAS No.: 1234480-50-2
• Molecular Formula: C26H30N6O3
• Molecular Weight: 474.6
• Storage: -20°C
• Availability: In Stock

Source

Original product source