ALV2 is a potent, selective degrader of the zinc-finger transcription factor Helios, which plays a role in maintaining Treg cell stability. By binding to cereblon (CRBN) with an IC50 of 0.57 μM, ALV2 promotes targeted Helios degradation, making it valuable for research involving transcriptional regulation and immune cell behavior. Reagent-grade; for laboratory research purposes only.
Products > PROTAC, Molecular glue > Degraders
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