ABT 737

Overview

ABT-737, a BH3 mimetic, is a potent Bcl-2 , Bcl-x L and Bcl-w inhibitor with EC 50 s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research.

Application

Products

Product Information

• Catalog No.: BP-25381
• CAS No.: 852808-04-9
• Molecular Formula: C42H45ClN6O5S2
• Molecular Weight: 813.43
• Purity: 95%
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source