GSK215 represents a highly effective and specific PROTAC designed to degrade focal adhesion kinase (FAK). Engineered with a binding affinity for both the VHL E3 ligase and the FAK inhibitor VS-4718, GSK215 facilitates swift and sustained degradation of FAK, resulting in a durable impact on FAK levels and a notable disconnect between pharmacokinetics/pharmacodynamics (PK/PD). Reagent-grade; for laboratory research purposes only.
Products > PROTAC, Molecular glue > Degraders
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